HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → 1-(But-2-en-1-yl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-phenoxycarbonyloxy-1-isoindolinone | HCID 23343637 | — |
| Product | 1-(But-2-en-1-yl)piperazine | HCID 53953079 | — |
Reaction Steps
Following the procedure of Example 36 but starting from 2-(7-chloro-1,8-naphthyridin-2-yl)-3-phenoxycarbonyloxy-1-isoindolinone (4.32 g.) and 1-(but-2-en-1-yl)-piperazine (7 g.) in acetonitrile (25 cc.), 3-[4-(but-2-en-1-yl)-1-piperazinyl]-carbonyloxy-2-(7-chloro-1,8-naphthyridin-2-yl)-1-isoindolinone (1.95 g.) melting at 190° C is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04016274 |
| Source dataset | uspto-grants-1977_04 |
| ORD ID | ord-da0cbc45e86e4bbfb01e57d01bb62060 |
| Source note | uspto-grants-1977_04 |