Methyl chloroformate → Trimethyl phosphonoformate

HRID 328290Notes

Reaction equation

HRID 328290 reaction equation
[P:1]([O:6][CH3:7])([O:4][CH3:5])[O:2]C.Cl[C:9]([O:11][CH3:12])=[O:10]>>[CH3:12][O:11][C:9]([P:1](=[O:2])([O:6][CH3:7])[O:4][CH3:5])=[O:10]

Participants

3

Reactant 2

HCID 6586Methyl chloroformateHCID 8472Trimethyl phosphite

Product 1

HCID 451443Trimethyl phosphonoformate

Procedure

One hundred and thirty parts of trimethyl phosphite are heated to 125° C. and treated with 100 parts of methyl chloroformate at a rate sufficient to maintain a reaction temperature of at least 100° C. After gas evolution stops, the residue is distilled to obtain 131 parts of dimethyl methoxycarbonylphosphonate, b.p. 83°-85° C./1.2 mm., nD25 = 1.4210.

Workup

  1. temperatureto maintain a reaction temperature of at least 100° C
  2. distillationthe residue is distilled

Sources & evidence

ORD record
ord-1477fd5b6d6c4e0db11d7c08b182c422
Source dataset
uspto-grants-1977_04
Patent number
US04017297

Reaction notes

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