反应详情

560 Gram of granular anhydrous aluminum chloride and 1 l of nitrobenzene were introduced into a 5 l three neck flask, and stirred under water-cooling to give a solution. A solution of 600 g of diphenyl and 482.5 g of n-valeric acid chloride dissolved in 1 l of nitrobenzene (prepared in advance) was dropwise added into said three neck flask over 2 hours. After the addition, the resulting mixture was stirred for one hour as it was. Thereafter it was stirred at 40°-45° C for 2 hours, cooled to room temperature, poured cautiously into a mixed solution of 1.3 l of conc. hydrochloric acid and 1.5 l of water for decomposing the catalyst, and cooled to 20° C. Precipitated crystal was separated by filtration. Nitrobenzene was distilled off from nitrobenzene layer by distillation under a reduced pressure to give an additional crystal. Both the crystals were recrystallized from ethanol to give 881 g of crystal of 4-n-pentanoylbiphenyl (m.p. 79°-79.5° C) (yield: 95% based on biphenyl).

1. temperaturecooling
2. customto give a solution
3. additionwas dropwise added
4. customover 2 hours
5. additionAfter the addition
6. stirringthe resulting mixture was stirred for one hour as it
7. stirringThereafter it was stirred at 40°-45° C for 2 hours
8. temperaturecooled to 20° C
9. customPrecipitated crystal
10. customwas separated by filtration
11. distillationNitrobenzene was distilled off from nitrobenzene layer by distillation under a reduced pressure
12. customto give an additional crystal
13. customBoth the crystals were recrystallized from ethanol