反应详情

温度

50 °C

Thousand gram of 4-n-pentanoylbiphenyl, 2 l of diethylene glycol and 564 g of potassium hydroxide were introduced into a 5 l three neck flask and warmed with stirring to give a uniform solution at about 80° C, which was then cooled to about 50° C, followed by adding 738 ml of hydrazine hydrate, heating with stirring, distilling off low boiling fractions (mainly water) until the temperature of the reaction mixture reached 185° C, heating under reflux at 185°-190° C for 4 hours, cooling to room temperature, adding 1.5 l of water and 400 ml of hexane, stirring, washing hexane layer with aqueous solution of sodium chloride, and distilling, to give 659 g of 4-n-pentylbiphenyl (b.p. 166°-167°/6 mmHg) (Yield 70%).

1. temperaturewarmed
2. customto give a uniform solution at about 80° C
3. temperatureheating
4. stirringwith stirring
5. distillationdistilling off low boiling fractions (mainly water) until the temperature of the reaction mixture
6. customreached 185° C
7. temperatureheating
8. temperatureunder reflux at 185°-190° C for 4 hours
9. temperaturecooling to room temperature
10. additionadding 1.5 l of water and 400 ml of hexane
11. stirringstirring
12. washwashing hexane layer with aqueous solution of sodium chloride
13. distillationdistilling