反应详情

392 Gram of granular anhydrous aluminum chloride and 700 ml of nitrobenzene were introduced into 5 l three neck flask, and dissolved with stirring. A solution of 600 g of 4-n-pentylbiphenyl and 220 g of acetyl chloride dissolved in 500 ml of nitrobenzene (prepared in advance) was dropwise added to said three neck flask over 1 hour, followed by stirring for one hour, further stirring at 40°-45° C for 2 hours, cooling to room temperature, pouring cautiously into a mixed liquid of 250 ml of conc. hydrochloric acid and 1.25 l of water, distilling off nitrobenzene from nitrobenzene layer by distillation under a reduced pressure, separating the resulting solid by filtration, and recrystallizing it from ethanol, to give 597 g of 4'-n-pentyl-4-acetylbiphenyl (m.p. 81°-82°) (Yield 84%).

1. dissolutiondissolved
2. additionwas dropwise added
3. customover 1 hour
4. stirringby stirring for one hour
5. stirringfurther stirring at 40°-45° C for 2 hours
6. distillationdistilling off nitrobenzene from nitrobenzene layer
7. distillationby distillation under a reduced pressure
8. customseparating the resulting solid
9. filtrationby filtration
10. customrecrystallizing it from ethanol