反应详情

A mixture of 8.5 g. (50 mmoles) of potassium 6-hydroxycaproate, 13.9 g. (50 mmoles) of p-bromophenacyl bromide, 0.75 g. (2 mmoles) of dicyclohexyl-18 -crown-6 in 500 ml. of acetonitrile is refluxed with stirring for 1 hour and stirred at room temperature overnight. The mixture is filtered and the filtrate evaporated to dryness in vacuo. The residual solid is recrystallized from benzene-hexane mixture affording 14.1 g. of p-bromophenacyl 6-hydroxycarproate, m.p. 79°-81° C.

1. additionA mixture of 8.5 g
2. stirringstirred at room temperature overnight
3. filtrationThe mixture is filtered
4. customthe filtrate evaporated to dryness in vacuo
5. customThe residual solid is recrystallized from benzene-hexane mixture
6. customaffording 14.1 g