Diazomethane → 7-Chloro-2-[[1-(methoxycarbonyl)ethylidene]-hydrazino]-5-phenyl-3H-1,4-benzodiazepine

HRID 328385Notes

Reaction equation

HRID 328385 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][N:13]=[C:14]([C:16]([OH:18])=[O:17])[CH3:15])[CH2:9][N:8]=[C:7]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:6]=2[CH:25]=1.[N+](=[CH2:28])=[N-]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][N:13]=[C:14]([C:16]([O:18][CH3:28])=[O:17])[CH3:15])[CH2:9][N:8]=[C:7]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)[C:6]=2[CH:25]=1

Participants

3

Reactant 2

HCID 9550DiazomethaneHCID 540541807-chloro-2-[(1-carboxyethylidene)hydrazino]-5-phenyl-3H-1,4-benzodiazepine

Product 1

HCID 537299667-Chloro-2-[[1-(methoxycarbonyl)ethylidene]-hydrazino]-5-phenyl-3H-1,4-benzodiazepine

Procedure

To this solution of 7-chloro-2-[(1-carboxyethylidene)hydrazino]-5-phenyl-3H-1,4-benzodiazepine under nitrogen, is added with stirring, 50 ml. (0.015 mole) of an ethereal 0.3 molar solution of diazomethane. After 10 minutes the solution is evaporated giving 7-chloro-2-[[1-(methoxycarbonyl)ethylidene]-hydrazino]-5-phenyl-3H-1,4-benzodiazepine is obtained.

Workup

  1. customAfter 10 minutes the solution is evaporated

Sources & evidence

ORD record
ord-173bfe818a744600856ff45cfda7f2e2
Source dataset
uspto-grants-1977_04
Patent number
US04017492

Reaction notes

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