2-Oxo-5-piperidinopentanoic acid → 7-nitro-2-[(1-carboxy-4-piperidinobutylidene)-hydrazino]-5-phenyl-3H-1,4-benzodiazepine

HRID 328412Notes

Reaction equation

HRID 328412 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:13]=[C:12]([NH:14][NH2:15])[CH2:11][N:10]=[C:9]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C:8]=2[CH:22]=1)([O-:3])=[O:2].O=[C:24]([CH2:28][CH2:29][CH2:30][N:31]1[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1)[C:25]([OH:27])=[O:26]>>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:13]=[C:12]([NH:14][N:15]=[C:24]([C:25]([OH:27])=[O:26])[CH2:28][CH2:29][CH2:30][N:31]3[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]3)[CH2:11][N:10]=[C:9]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C:8]=2[CH:22]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 214416812-Oxo-5-piperidinopentanoic acidHCID 22768399HCID 22768399, compound

Product 1

HCID 543095357-nitro-2-[(1-carboxy-4-piperidinobutylidene)-hydrazino]-5-phenyl-3H-1,4-benzodiazepine

Procedure

In the manner given in Example 13, 7-nitro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine can be stirred with 2-oxo-5-piperidinopentanoic acid at room temperature to give 7-nitro-2-[(1-carboxy-4-piperidinobutylidene)-hydrazino]-5-phenyl-3H-1,4-benzodiazepine.

Sources & evidence

ORD record
ord-a0fe5fd48b1d458b993b243af9db277d
Source dataset
uspto-grants-1977_04
Patent number
US04017492

Reaction notes

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