2-hydrazino-5-phenyl-3H-1,4-benzodiazepine → 2-[[1-carboxy-3-(dimethylamino)propylidene]hydrazino]-5-phenyl-3H-1,4-benzodiazepine

HRID 328419Notes

Reaction equation

HRID 328419 reaction equation
[NH:1]([C:3]1[CH2:9][N:8]=[C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:6]2[CH:16]=[CH:17][CH:18]=[CH:19][C:5]=2[N:4]=1)[NH2:2].[CH3:20][N:21]([CH3:29])[CH2:22][CH2:23][C:24](=O)[C:25]([OH:27])=[O:26]>>[C:25]([C:24](=[N:2][NH:1][C:3]1[CH2:9][N:8]=[C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:6]2[CH:16]=[CH:17][CH:18]=[CH:19][C:5]=2[N:4]=1)[CH2:23][CH2:22][N:21]([CH3:29])[CH3:20])([OH:27])=[O:26]

Participants

3

Reactant 2

HCID 126123892-hydrazino-5-phenyl-3H-1,4-benzodiazepineHCID 214415744-(Dimethylamino)-2-oxobutanoic acid

Product 1

HCID 539803182-[[1-carboxy-3-(dimethylamino)propylidene]hydrazino]-5-phenyl-3H-1,4-benzodiazepine

Procedure

In the manner given in Example 13, 2-hydrazino-5-phenyl-3H-1,4-benzodiazepine can be stirred with 4-(dimethylamino)-2-oxobutyric acid at room temperature to give 2-[[1-carboxy-3-(dimethylamino)propylidene]hydrazino]-5-phenyl-3H-1,4-benzodiazepine.

Sources & evidence

ORD record
ord-3e74a5f4b9e94886b87e8bfc5e91b106
Source dataset
uspto-grants-1977_04
Patent number
US04017492

Reaction notes

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