反应详情

To a solution of (4-dimethylcarbamoyl-thiazol-2-yl)-carbamic acid tert-butyl ester (0.26 g, 0.95 mmol) in dichloromethane (10 mL) was added trifluoroacetic acid (10 mL, 130 mmol). The reaction mixture was stirred at room temperature for 2 hours, then concentrated under reduced pressure. Saturated aqueous sodium bicarbonate solution (50 mL) was added to neutralize the residue. The mixture was extracted with ethyl acetate (2×100 mL). The organic layers were separated, combined and dried over sodium sulfate, concentrated under reduced pressure and dried in vacuo to give crude 2-amino-thiazole-4-carboxylic acid dimethylamide as a yellow gum which was used without further purification (0.14 g, 86%).

1. concentrationconcentrated under reduced pressure
2. additionSaturated aqueous sodium bicarbonate solution (50 mL) was added
3. extractionThe mixture was extracted with ethyl acetate (2×100 mL)
4. customThe organic layers were separated
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated under reduced pressure
7. customdried in vacuo