反应详情

A mixture of 1.9 g of N-(3-chloropropyl)-p-fluoroaniline, 1.9 g of 1-(o-methoxyphenyl)piperazine, 0.5 g of sodium carbonate and 50 ml of dimethylformamide was heated at 80°-90° C for 15 hours. After cooling, the reaction mixture was poured into water and extracted with benzene. The extract was washed with water, dried over sodium sulfate and evaporated under reduced pressure to give 1-{3-(p-fluoroanilino)propyl}-4-(o-methoxyphenyl)piperazine, m.p. 79°-80° C; recrystallized from cyclohexane, m.p. 84°-84.5° C.

1. temperaturewas heated at 80°-90° C for 15 hours
2. temperatureAfter cooling
3. extractionextracted with benzene
4. washThe extract was washed with water
5. dry with materialdried over sodium sulfate
6. customevaporated under reduced pressure