Diethyl (ethoxymethylene)malonate → HCID 13051078, compound

HRID 328572Notes

Reaction equation

HRID 328572 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH2:9]2)[CH:5]=[CH:4][CH:3]=1.C(O[CH:18]=[C:19]([C:25]([O:27][CH2:28][CH3:29])=[O:26])[C:20]([O:22][CH2:23][CH3:24])=[O:21])C>>[CH3:14][N:11]1[CH2:10][CH2:9][N:8]([C:6]2[N:7]=[C:2]([NH:1][CH:18]=[C:19]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:25]([O:27][CH2:28][CH3:29])=[O:26])[CH:3]=[CH:4][CH:5]=2)[CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 6871Diethyl (ethoxymethylene)malonateHCID 219614276-(4-methylpiperazin-1-yl)pyridin-2-amine

Product 1

HCID 13051078HCID 13051078, compound

Conditions

Temperature
90 °C

Procedure

A mixture containing 2.5 g of 6-amino-2-(4-methyl-1-piperazinyl)pyridine and 3.1 g of diethyl ethoxymethylenemalonate was heated at 90° C for 2 hours and then chilled. The resulting solid was recrystallized from benzene to give the product, m.p. 114°- 115° C.

Workup

  1. temperaturechilled
  2. customThe resulting solid was recrystallized from benzene
  3. customto give the product, m.p. 114°- 115° C.

Sources & evidence

ORD record
ord-f4d2f47f94e54937a32ef15ab257ada9
Source dataset
uspto-grants-1977_04
Patent number
US04017622

Reaction notes

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