Acetyl chloride → HCID 21442817, compound

HRID 328583Notes

Reaction equation

HRID 328583 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH:3]([CH2:7][N:8]2[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=3[CH2:12][CH2:11][C:10]3[CH:19]=[CH:20][CH:21]=[CH:22][C:9]2=3)[CH2:2]1.[C:23](Cl)(=[O:25])[CH3:24]>C1C=CC=CC=1>[C:23]([N:1]1[CH2:6][CH2:5][O:4][CH:3]([CH2:7][N:8]2[C:9]3[CH:22]=[CH:21][CH:20]=[CH:19][C:10]=3[CH2:11][CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]2=3)[CH2:2]1)(=[O:25])[CH3:24]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 13277196HCID 13277196, compound

Product 1

HCID 21442817HCID 21442817, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To a solution of 5-(2-morpholinylmethyl)-10,11-dihydro-5H-dibenz[b,f]azepine (0.34 g) in anhydrous benzene was added excess acetyl chloride under ice cooling. After stirring for 4 hours, the reaction mixture was washed with aqueous 2N sodium hydroxide and then with water, dried and evaporated to afford 5-(4-acetyl-2-morpholinylmethyl)-10,11-dihydro-5H-dibenz[b,f]azepine as an oily substance.

Workup

  1. washthe reaction mixture was washed with aqueous 2N sodium hydroxide
  2. dry with materialwith water, dried
  3. customevaporated

Sources & evidence

ORD record
ord-8a31cc4c59184f159c4c982c0ef50676
Source dataset
uspto-grants-1977_04
Patent number
US04017621

Reaction notes

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