Hydrochloric Acid → HCID 21439774, compound

HRID 328688Notes

Reaction equation

HRID 328688 reaction equation
[C:1]([OH:11])(=O)[C:2]1[C:3](=[CH:6][CH:7]=[CH:8][CH:9]=1)[CH:4]=O.C(O)C.[CH2:15]([NH2:18])[CH2:16][NH2:17].[ClH:19]>CO>[ClH:19].[NH:17]1[CH:4]2[C:3]3[C:2]([C:1](=[O:11])[N:18]2[CH2:15][CH2:16]1)=[CH:9][CH:8]=[CH:7][CH:6]=3

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 3301EthylenediamineHCID 8406Phthalaldehydic acid

Product 1

HCID 21439774HCID 21439774, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 7.5 g. of phthalaldehydic acid in 30 ml. of ethanol and 34 ml. of ethylenediamine was refluxed for 16 hours. The solution was concentrated in vacuo and the residue was dissolved in methylene chloride. The solution was washed with water, dried and concentrated. The residue was distilled in a bulb tube at 0.3 mm at a bath temperature of 150°-180°. A colorless oil was obtained which was dissolved in methanol and on addition of ethereal hydrogen chloride gave white prisms of 1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-one hydrochloride, m.p. 222°-224° dec.

Workup

  1. concentrationThe solution was concentrated in vacuo
  2. dissolutionthe residue was dissolved in methylene chloride
  3. washThe solution was washed with water
  4. customdried
  5. concentrationconcentrated
  6. distillationThe residue was distilled in a bulb tube at 0.3 mm at a bath temperature of 150°-180°
  7. customA colorless oil was obtained which

Sources & evidence

ORD record
ord-ff98de2959c24abe9e8c8664a2b14849
Source dataset
uspto-grants-1977_04
Patent number
US04018765

Reaction notes

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