Phosphorus sulfide (P2S5) → HCID 9838314, compound

HRID 328719Notes

Reaction equation

HRID 328719 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[NH:12][C:11](=O)[CH2:10][N:9]=1.P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:21]>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[NH:12][C:11](=[S:21])[CH2:10][N:9]=1

Participants

3

Reactant 2

HCID 14817Phosphorus sulfide (P2S5)HCID 132920741,4-BENZODIAZPIN-2-ONE,5-(2-F PH)

Product 1

HCID 9838314HCID 9838314, compound

Procedure

A mixture of 1,3-dihydro-5-(o-fluorophenyl)-2H-1,4-benzodiazepin-2-one [Sternbach et al., J. Org. Chem. 27, 3788 (1962)] and P2S5 can be reacted in the same manner as in preparation I to produce 1,3-dihydro-5-(o-fluorophenyl)-2H-1,4-benzodiazepine-2-thione. This latter compound can then be substituted in the procedure of Exmple 1 to produce 6-(o-fluorophenyll)-1methyl-4H-s-triazolo[4,3-a] [1,4] benzodiazepine.

Workup

  1. customcan be reacted in the same manner as in preparation I

Sources & evidence

ORD record
ord-f0bbb311e87e474b9c0e21fdcd73aab7
Source dataset
uspto-grants-1977_04
Patent number
US04018788

Reaction notes

Loading…