Phosphorus sulfide (P2S5) → HCID 9838314, compound

Participants

Reaction Steps

A mixture of 1,3-dihydro-5-(o-fluorophenyl)-2H-1,4-benzodiazepin-2-one [Sternbach et al., J. Org. Chem. 27, 3788 (1962)] and P2S5 can be reacted in the same manner as in preparation I to produce 1,3-dihydro-5-(o-fluorophenyl)-2H-1,4-benzodiazepine-2-thione. This latter compound can then be substituted in the procedure of Exmple 1 to produce 6-(o-fluorophenyll)-1methyl-4H-s-triazolo[4,3-a] [1,4] benzodiazepine.

Provenance & Evidence