Methylamine → HCID 54395090, compound

HRID 328734Notes

Reaction equation

HRID 328734 reaction equation
Cl[C:2]1[C:7]2[CH:8]=[N:9][N:10]([CH2:11][CH3:12])[C:6]=2[N:5]=[C:4]2[CH2:13][CH2:14][C:15]3[CH:22]=[CH:21][CH:20]=[CH:19][C:16]=3[C:17](=[O:18])[C:3]=12.[CH3:23][NH2:24]>>[CH2:11]([N:10]1[C:6]2[N:5]=[C:4]3[CH2:13][CH2:14][C:15]4[CH:22]=[CH:21][CH:20]=[CH:19][C:16]=4[C:17](=[O:18])[C:3]3=[C:2]([NH:24][CH3:23])[C:7]=2[CH:8]=[N:9]1)[CH3:12]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 22758787HCID 22758787, compound

Product 1

HCID 54395090HCID 54395090, compound

Procedure

8.4 g. of 4-chloro-1ethyl-10,11-dihydrobenzo [4,5]cyclohepta [1,2-b ]pyrazolo [4,3-e ]pyridin-5(1H)one (0.027 mol.) dissolved in 90 ml. of an alcoholic methylamine solution (270 g/1) are allowed to stand at room temperature for five hours. After this time, 7.1 g. of precipitated 1-ethyl-10,11-dihydro-4-(methylamino)benzo [4,5]cyclohepta [1,2-b ]pyrazolo-[4,3-e ]pyridin-5(1H)one are collected, m.p. 148°-150°. A sample recrystallized from absolute ethanol melts at 149°-150°.

Workup

  1. customof precipitated 1-ethyl-10,11-dihydro-4-(methylamino)benzo [4,5]cyclohepta [1,2-b ]pyrazolo-[4,3-e ]pyridin-5(1H)one are collected
  2. customA sample recrystallized from absolute ethanol melts at 149°-150°

Sources & evidence

ORD record
ord-81d60a7326164a04969f57db609620cb
Source dataset
uspto-grants-1977_04
Patent number
US04018779

Reaction notes

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