反应详情

2-Mercaptoethanol (31.2 g., 0.4 mole) is dissolved in a solution of sodium (9.2 g., 0.4 mole) in methanol (300 ml.). Ethyl 8-bromo-12-acetoxy-heptadecanoate (Example 1, Step E) (43.5 g., 0.1 mole) is added and the resulting solution is heated at reflux for 5 hours. Most of the methanol is then removed by evaporation in vacuo. Water (350 ml.) is added to the residue and the oily product taken up in ether, washed with water and brine and dried over sodium sulfate. Evaporation of the ether leaves the title compound as a yellow residual oil which is used in the next step without further purification.

1. temperaturethe resulting solution is heated
2. temperatureat reflux for 5 hours
3. customMost of the methanol is then removed by evaporation in vacuo
4. additionWater (350 ml.) is added to the residue
5. washwashed with water and brine
6. dry with materialdried over sodium sulfate
7. customEvaporation of the ether