Acetone → (3-trifluoromethyl-phenoxy)-acetaldehyde

HRID 328797Notes

Reaction equation

HRID 328797 reaction equation
C([O:3][CH:4](OCC)[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=1)C.CC(C)=O.S(=O)(=O)(O)O>O>[F:14][C:13]([F:15])([F:16])[C:9]1[CH:8]=[C:7]([CH:12]=[CH:11][CH:10]=1)[O:6][CH2:5][CH:4]=[O:3]

Participants

5

Reactant 3

HCID 180AcetoneHCID 1118Sulfuric AcidHCID 126618001-(2,2-Diethoxyethoxy)-3-(trifluoromethyl)benzene

Product 1

HCID 11252687(3-trifluoromethyl-phenoxy)-acetaldehyde

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 3-trifluoromethylphenoxyacetaldehyde diethyl acetal (146.3 g.; 0.527 mole), acetone (600 ml.), water (550 ml.), and concentrated sulfuric acid (3.5 ml.) is heated under reflux for 22 hours.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 22 hours

Sources & evidence

ORD record
ord-cb144d0b78e946e5b21ad719980ac65f
Source dataset
uspto-grants-1977_04
Patent number
US04018802

Reaction notes

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