Propylamine → HCID 12787979, compound

HRID 328816Notes

Reaction equation

HRID 328816 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][CH:8]2[C:11](Cl)=[O:12])=[CH:4][C:3]=1[CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1.[CH2:20]([NH2:23])[CH2:21][CH3:22]>C1C=CC=CC=1>[CH2:20]([NH:23][C:11]([CH:8]1[C:9]2[C:5](=[CH:4][C:3]([CH:14]3[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]3)=[C:2]([Cl:1])[CH:10]=2)[CH2:6][CH2:7]1)=[O:12])[CH2:21][CH3:22]

Participants

4

Reactant 2

HCID 7852PropylamineHCID 21440591HCID 21440591, compound

Product 1

HCID 12787979HCID 12787979, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

In 35 ml. of benzene is dissolved 2.97 g. of 6-chloro-5-cyclohexylindan-1-carbonyl chloride and to the solution is added 1.77 g. of n-propylamine under cooling and with stirring. The mixture is stirred at room temperature for 1 hour, after which time it is washed with water and dried over anhydrous magnesium sulfate. The solvent is evaporated under reduced pressure and the residual crystals are recrystallized from acetone. The procedure yields N-propyl-6-chloro-5-cyclohexylindan-1-carboxamide, Melting poing: 140.5 - 142.5° C.

Workup

  1. stirringThe mixture is stirred at room temperature for 1 hour
  2. washafter which time it is washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent is evaporated under reduced pressure
  5. customthe residual crystals are recrystallized from acetone

Sources & evidence

ORD record
ord-424925b3ba044f998a91bcca993da4cd
Source dataset
uspto-grants-1977_04
Patent number
US04018817

Reaction notes

Loading…