反应详情

温度

130 °C

A mixture of 4.8 parts of 1-(tert.-butyl)-3-azetidinol, 6.1 parts of 2,3-xylenol and 1.4 parts of trifluoroacetic acid was heated at 130° C. for 12 hours. The reaction mixture was cooled and dissolved in 100 parts of ether, and the solution was washed three times with 50 parts of 2N-sodium hydroxide aqueous solution and extracted three times with 2N-hydrochloric acid aqueous solution. The extract was washed twice with 50 parts of ether and made alkaline by addition of 2N-sodium hydroxide solution. The extraction was conducted three times with 50 parts of ether, and the extract was condensed and distilled under reduced pressure to yield 3.2 parts of 1-(2',3'-dimethylphenyloxy)-3-(tert.-butylamino)-2-propanol having a melting point of 57° C. and a boiling point of 134°-136° C. under 0.7 mm Hg.

1. temperatureThe reaction mixture was cooled
2. washthe solution was washed three times with 50 parts of 2N-sodium hydroxide aqueous solution
3. extractionextracted three times with 2N-hydrochloric acid aqueous solution
4. washThe extract was washed twice with 50 parts of ether
5. additionby addition of 2N-sodium hydroxide solution
6. extractionThe extraction
7. customcondensed
8. distillationdistilled under reduced pressure