反应详情

温度

180 °C

A mixture of 17.3 parts of β-naphthol, 20.5 parts of 1-(iso-propyl)-3-benzyloxyazetidine, and 1.1 parts of potassium hydroxide was heated under nitrogen gas at 180° C. for 8 hours with agitation. The reaction mixture was cooled and dissolved in 100 parts of ether. The solution was washed with 50 parts of 2N-sodium hydroxide aqueous solution and dried over anhydrous sodium sulfate. Ether was distilled off and the residue was subjected to distillation to yield 29.3 parts of 1-(β-naphthoxy)-2-benzyloxy-3-(iso-propylamino)propane boiling at 185° -190° C. under 1 mm Hg. The yield was 84%. The results of infra-red spectrum analysis and nuclear magnetic resonance analysis of the product are as follows:

1. temperatureThe reaction mixture was cooled
2. washThe solution was washed with 50 parts of 2N-sodium hydroxide aqueous solution
3. dry with materialdried over anhydrous sodium sulfate
4. distillationEther was distilled off
5. distillationthe residue was subjected to distillation