反应详情

温度

90 °C

21.9 parts of 2-benzyloxy-1,3-dichloro-propane, 71.3 parts of tert.-butylamine and 50 parts of water were added to an autoclave and the mixture was heated at 90° C. for 48 hours with agitation. The reaction mixture was cooled and treated in the same manner as in Example 29, followed by distillation under reduced pressure. As a result 17.5 parts of 3-benzyloxy-1-(tert.-butyl)azetidine boiling at 94° - 96° C. under 2 mm Hg were obtained. The yield was 80%. The results of infra-red spectrum analysis and nuclear magnetic resonance anlaysis are as follows:

1. temperatureThe reaction mixture was cooled
2. additiontreated in the same manner as in Example 29
3. distillationfollowed by distillation under reduced pressure