Methylamine → HCID 20517347, compound

HRID 328904Notes

Reaction equation

HRID 328904 reaction equation
[CH3:1][O:2][C:3]1[CH:15]=[CH:14][C:6]([CH2:7][O:8][CH:9]([CH2:12]Br)[CH2:10]Br)=[CH:5][CH:4]=1.[CH3:16][NH2:17]>O>[CH3:1][O:2][C:3]1[CH:15]=[CH:14][C:6]([CH2:7][O:8][CH:9]2[CH2:12][N:17]([CH3:16])[CH2:10]2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 20517362HCID 20517362, compound

Product 1

HCID 20517347HCID 20517347, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
90 °C

Procedure

33.7 parts of 2-(p-methoxybenzyloxy)-1,3-dibromopropane, 70 parts of monomethylamine and 70 parts of water were added to in an autoclave, and the mixture was heated at 90° C. for 48 hours with agitation. The reaction mixture was cooled and treated in the same manner as in Example 29, followed by distillation under reduced pressure. As a result 11.7 parts of 3-(p-methoxybenzyloxy)-1-methylazetidine boiling at 85° - 87° C. under 2 mm Hg were obtained.

Workup

  1. temperatureThe reaction mixture was cooled
  2. additiontreated in the same manner as in Example 29
  3. distillationfollowed by distillation under reduced pressure

Sources & evidence

ORD record
ord-2b73a48573db4bbdb73af1d9cfc56347
Source dataset
uspto-grants-1977_04
Patent number
US04018824

Reaction notes

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