Diethyl Ether → HCID 53635157, compound

HRID 328958Notes

Reaction equation

HRID 328958 reaction equation
C(O)(=O)[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[Cl-].[C:13]([C:21]1[C:26]([N+:27]([O-:29])=[O:28])=[CH:25][C:24]([C:30]([OH:32])=[O:31])=[CH:23][C:22]=1[N+]#N)(=[O:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.O.O.O.C([O-])(=O)C.[Na+].C(OCC)C>C(#N)C.O>[C:13]([C:21]1[C:26]([N+:27]([O-:29])=[O:28])=[CH:25][C:24]([C:30]([OH:32])=[O:31])=[CH:23][C:22]=1[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=[O:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

7

Reactant 4

HCID 3283Diethyl EtherHCID 87842-Propenoic acid, 3-phenyl-HCID 21440138HCID 21440138, compoundHCID 23665404Sodium Acetate Trihydrate

Product 1

HCID 53635157HCID 53635157, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolvent3×HCID 6342AcetonitrileSolvent

Procedure

To a solution of cinnamic acid (3.1 g) in acetonitrile (200 ml), moist 2-benzoyl-5-carboxy-3-nitrobenzenediazonium chloride (corresponding to about 8 g dry material) is added. To the vigorously stirred suspension, a solution of sodium acetate trihydrate (9.4 g) in water (160 ml) is added, followed immediately by a solution of cupric chloride dihydrate (1 g) in water (10 ml). After stirring at room temperature for a further 2 hours, the vigorous nitrogen-evolution has subsided and the mixture is diluted with water (180 ml) followed by diethyl ether (130 ml). The mixture is filtered, and the organic layer is separated. The aqueous layer is extracted with five portions of diethyl ether, and the combined ether extracts are washed with water and evaporated in vacuo. The residue is crystallized by trituration with aqueous ethanol (50-100 ml). The crude 4-benzoyl-5-nitro-3-styrylbenzoic acid obtained is collected by filtration, washed with aqueous ethanol and dried. The crude acid is dissolved in hot 1 N sodium hydrogen carbonate, and after cooling, the precipitated sodium 4-benzoyl-5-nitro-3-styrylbenzoate is collected by filtration and washed with a small amount of icecold water. After drying, the salt is dissolved in hot water (100 ml) and the solution is clairied by filtration hot in the presence of decolorizing carbon. 4-Benzoyl-5-nitro-3-styrylbenzoic acid is precipitated by acidification with acetic acid. It is collected by filtration and is, after drying, obtained with a melting point of 288°-289° C. (dec.).

Workup

  1. filtrationThe mixture is filtered
  2. customthe organic layer is separated
  3. extractionThe aqueous layer is extracted with five portions of diethyl ether
  4. washthe combined ether extracts are washed with water
  5. customevaporated in vacuo
  6. customThe residue is crystallized by trituration with aqueous ethanol (50-100 ml)

Sources & evidence

ORD record
ord-c3aa4c3197ab4704b79adee24364470a
Source dataset
uspto-grants-1977_04
Patent number
US04018794

Reaction notes

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