1-Oxo-1H-isothiochromene-3-carboxylic acid → HCID 178526106, compound

HRID 328976Notes

Reaction equation

HRID 328976 reaction equation
[O:1]=[C:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[CH:5]=[C:4](C(O)=O)[S:3]1.[C:15](=O)([OH:17])[O-:16].[Na+:19]>O>[O:1]=[C:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[CH:5]=[CH:4][SH:3]1[C:15]([O-:17])=[O:16].[Na+:19]

Participants

4

Reactant 2

HCID 3455601-Oxo-1H-isothiochromene-3-carboxylic acidHCID 516892Sodium Bicarbonate

Product 1

HCID 178526106HCID 178526106, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a stirred suspension of 4.50 g. (21.8 mM) of the carboxylic acid of Example 2 in 200 ml. of distilled water is added 1.833 g. (21.82 mM) of sodium bicarbonate. The mixture is then stirred at 25°-35° for 2 hours, whereupon all the solids dissolve. The solution is frozen and freeze-dried to give sodium 1-oxo-1H-2-benzothiopyran-2-carboxylate as a pale yellow solid, m.p. >350°.

Workup

  1. additionTo a stirred suspension of 4.50 g
  2. dissolutiondissolve
  3. temperatureThe solution is frozen
  4. customfreeze-dried

Sources & evidence

ORD record
ord-8c990f6a004c48b5a5b06986e7fa16c7
Source dataset
uspto-grants-1977_04
Patent number
US04018891

Reaction notes

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