Sodium Bicarbonate → sodium 8-methoxy-1-oxo-1H-2-benzothiopyran-3-carboxylate

HRID 328985Notes

Reaction equation

HRID 328985 reaction equation
[CH3:1][O:2][C:3]1[C:12]2[C:11](=[O:13])[S:10][C:9]([C:14]([OH:16])=[O:15])=[CH:8][C:7]=2[CH:6]=[CH:5][CH:4]=1.C(=O)(O)[O-].[Na+:21]>O>[CH3:1][O:2][C:3]1[C:12]2[C:11](=[O:13])[S:10][C:9]([C:14]([O-:16])=[O:15])=[CH:8][C:7]=2[CH:6]=[CH:5][CH:4]=1.[Na+:21]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 214407508-methoxy-1-oxo-1H-2-benzothiopyran-3-carboxylic acid

Product 1

HCID 23666646sodium 8-methoxy-1-oxo-1H-2-benzothiopyran-3-carboxylate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a stirred suspension of 2.0221 g. (8.560 mM) of 8-methoxy-1-oxo-1H-2-benzothiopyran-3-carboxylic acid in 50 ml. of distilled water is added 0.7191 g. (8.560 mM) of sodium bicarbonate. The solid dissolves fairly rapidly and after stirring at 25° for 1 hour the solution is filtered and the filtrate freeze-dried to give sodium 8-methoxy-1-oxo-1H-2-benzothiopyran-3-carboxylate as a yellow solid, m.p. 307° (dec.).

Workup

  1. additionTo a stirred suspension of 2.0221 g
  2. dissolutionThe solid dissolves fairly rapidly
  3. filtrationis filtered
  4. customthe filtrate freeze-dried

Sources & evidence

ORD record
ord-5c6b94cee4d84013b617fb76c11b5f2d
Source dataset
uspto-grants-1977_04
Patent number
US04018891

Reaction notes

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