Hydrochloric Acid → HCID 21440739, compound

HRID 328990Notes

Reaction equation

HRID 328990 reaction equation
[C:1]([C:4]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[C:5]=1[CH:6]=[C:7]1[S:11]C(=S)N[C:8]1=[O:13])([OH:3])=O.[OH-:20].[Na+].Cl>>[CH3:19][O:18][C:14]1[C:5]2[CH:6]=[C:7]([C:8]([OH:20])=[O:13])[S:11][C:1](=[O:3])[C:4]=2[CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 54339098HCID 54339098, compound

Product 1

HCID 21440739HCID 21440739, compound

Procedure

A solution of 0.6 g. (2 mM) of the benzylidenerhodanine of Example 16 in 10 ml. of 15% NaOH is refluxed under nitrogen for 0.5 hour, cooled, and poured into cold dilute HCl to form a tan precipitate. The solid is collected, washed with water and recrystallized from methanol to give 5-methoxy-1-oxo-1H-2-benzothiopyran-3-carboxylic acid as yellow needles, m.p. 283°-284°.

Workup

  1. temperaturecooled
  2. customto form a tan precipitate
  3. customThe solid is collected
  4. washwashed with water
  5. customrecrystallized from methanol

Sources & evidence

ORD record
ord-8631088369934ff0bf17822f85d5091f
Source dataset
uspto-grants-1977_04
Patent number
US04018891

Reaction notes

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