Ethyl Acetoacetate → HCID 20570944, compound

HRID 328995Notes

Reaction equation

HRID 328995 reaction equation
C(O[C:4](=[O:9])[CH2:5][C:6]([CH3:8])=O)C.[CH2:10]([CH:13]([NH:20][NH2:21])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH2:11][CH3:12]>C(O)C>[CH3:8][C:6]1[NH:21][N:20]([CH:13]([CH2:10][CH2:11][CH3:12])[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:4](=[O:9])[CH:5]=1

Participants

4

Reactant 2

HCID 8868Ethyl AcetoacetateHCID 19855707HCID 19855707, compound

Product 1

HCID 20570944HCID 20570944, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

13 g of acetoacetic acid ethyl ester were dissolved in 20 ml of absolute ethanol. 16.4 g of α-n-propylbenzylhydrazine in a little absolute ethanol were slowly added to this solution under nitrogen. After the exothermic reaction had subsided, the mixture was heated for 2 hours under reflux.

Workup

  1. customAfter the exothermic reaction
  2. temperaturethe mixture was heated for 2 hours
  3. temperatureunder reflux

Sources & evidence

ORD record
ord-fe1baecc0ea1441a9543a160505b6c41
Source dataset
uspto-grants-1977_04
Patent number
US04018890

Reaction notes

Loading…