反应详情

A solution of 2-(3-aminopropylamino)pyridine (2.74 g.) and methyl isothiocyanate (1.46 g.) in isopropyl alcohol (50 ml.) was stirred at room temperature for 16 hours. Concentration, followed by trituration of the residue under methyl ethyl ketone gave the crude product which was recrystallised from aqueous ethanol to give N-methyl-N'-[3-(2-pyridylamino)propyl]thiourea (2.45 g.), m.p. 134°-135°. (Found: C, 53.4; H, 7.2; N, 25.0; S, 14.3. C10H16N4S requires: C, 53.5; H, 7.2; N, 25.0; S, 14.3).

1. concentrationConcentration
2. customgave the crude product which
3. customwas recrystallised from aqueous ethanol