Methane → HCID 21440946, compound

HRID 329030Notes

Reaction equation

HRID 329030 reaction equation
C([N:8]1[CH2:13][CH2:12][C:11]([CH3:18])([O:14][CH2:15][CH2:16][OH:17])[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H].C>C(O)C>[CH3:18][C:11]1([O:14][CH2:15][CH2:16][OH:17])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

5

Reactant 3

HCID 297MethaneHCID 21440967HCID 21440967, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 21440946HCID 21440946, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 51.5 g of 2-(1-benzyl-4-methyl-4-piperidyloxy)-ethanol in 500 ml of absolute ethanol was reacted with hydrogen at 50° C in the presence of 5 g of 5% palladized charcoal until the theoretical amount of hydrogen was absorbed (about 31/2 hours) and the catalyst was then filtered off. The ethanol was evaporated and the residue was distilled under reduced pressure to obtain 24 g of 2-(4-methyl-4-piperidyloxy) -ethanol as a colorless oil boiling at 80°-86° C at 0.01 mm Hg and having a refractive index nD24 = 1.481.

Workup

  1. customwas absorbed (about 31/2 hours)
  2. filtrationthe catalyst was then filtered off
  3. customThe ethanol was evaporated
  4. distillationthe residue was distilled under reduced pressure

Sources & evidence

ORD record
ord-75737e78d8494d50a5541fbf293d55a9
Source dataset
uspto-grants-1977_04
Patent number
US04018922

Reaction notes

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