Methane → 2-(4-Ethyl-4-piperidyloxy)-ethanol

HRID 329032Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 329032
C([N:8]1[CH2:13][CH2:12][C:11]([CH2:18][CH3:19])([O:14][CH2:15][CH2:16][OH:17])[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H].C>C(O)C>[CH2:18]([C:11]1([O:14][CH2:15][CH2:16][OH:17])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)[CH3:19]

Komponenten

5

Edukt 3

HCID 297MethaneHCID 214409512-(1-Benzyl-4-ethyl-4-piperidyloxy)-ethanolHCID 178418361HCID 178418361, Verbindung2×

Produkt 1

HCID 214409042-(4-Ethyl-4-piperidyloxy)-ethanolAusbeute 78,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 37 g of 2-(1-benzyl-4-ethyl-4-piperidyloxy)-ethanol in 300 ml of absolute ethanol was reacted with hydrogen at 50° C in the presence of 4 g of 10% palladized charcoal until the theoretical amount of hydrogen was absorbed (about 3 hours) and the catalyst was filtered off. The ethanol was evaporated off and the residue was distilled to obtain 19.2 g of 2-(4-ethyl-4-piperidyloxy)-ethanol as a colorless oil boiling at 102°-106° C at 0.5 mm Hg.

Aufarbeitung

  1. customwas absorbed (about 3 hours)
  2. filtrationthe catalyst was filtered off
  3. customThe ethanol was evaporated off
  4. distillationthe residue was distilled

Quellen und Nachweise

ORD-Eintrag
ord-64e96c58d7664913b2c0bc3b50b86bf8
Quelldatensatz
uspto-grants-1977_04
Patentnummer
US04018922

Notizen zur Reaktion

Wird geladen…