HRID329042

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID78282

Benzoyl chloride, 3,4,5-trimethoxy-

C10H11ClO4

结构：OCCOC1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1

HCID218089

2-((1-(3-(2-(Trifluoromethyl)phenothiazin-10-yl)propyl)-4-piperidyl)oxy)ethanol

C23H27F3N2O2S

PRODUCTS

生成物

结构：COc1cc(C(=O)OCCOC2CCN(CCCN3c4ccccc4Sc4ccc(C(F)(F)F)cc43)CC2)cc(OC)c1OC

HCID21440927

未命名化合物

收率 33%

PROCEDURE

实验过程

Using the procedure of Example XXXV, 18.7 g (0.04 mole) of 2-trifluoromethyl-10-[3-(4-β-hydroxyethoxy-piperidino)-propyl]-phenothiazine (prepared in Example XXIII) and 9.2 g (0.04 mole) of 3,4,5-trimethoxy-benzoyl chloride were reacted to obtain 8.5 g (33% yield) of 2-trifluoromethyl-10-[ 3{ 4-[2-(3,4,5-trimethoxy-benzoyloxy)-ethoxy]-piperidino}-propyl]-phenothiazine as a clear amber oil

WORKUP

后处理

customwere reacted

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-590cbc7787f34e64aa1061e0abd7d3b1
来源数据集: uspto-grants-1977_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04018922
来源说明: uspto-grants-1977_04

反应 SMILES

[F:1][C:2]([F:31])([F:30])[C:3]1[CH:16]=[CH:15][C:14]2[S:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[N:6]([CH2:17][CH2:18][CH2:19][N:20]3[CH2:25][CH2:24][CH:23]([O:26][CH2:27][CH2:28][OH:29])[CH2:22][CH2:21]3)[C:5]=2[CH:4]=1.[CH3:32][O:33][C:34]1[CH:35]=[C:36]([CH:40]=[C:41]([O:45][CH3:46])[C:42]=1[O:43][CH3:44])[C:37](Cl)=[O:38]>>[F:31][C:2]([F:30])([F:1])[C:3]1[CH:16]=[CH:15][C:14]2[S:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[N:6]([CH2:17][CH2:18][CH2:19][N:20]3[CH2:21][CH2:22][CH:23]([O:26][CH2:27][CH2:28][O:29][C:37](=[O:38])[C:36]4[CH:35]=[C:34]([O:33][CH3:32])[C:42]([O:43][CH3:44])=[C:41]([O:45][CH3:46])[CH:40]=4)[CH2:24][CH2:25]3)[C:5]=2[CH:4]=1