Hydrochloric Acid → Ethanol, 2-((4-methyl-1-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-4-piperidinyl)oxy)-, monohydrochloride

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Reaction Steps

The 2-trifluoromethyl-10-[3-(4-β-hydroxyethoxy-4-methyl piperidino)-propyl]-phenothiazine was reacted in acetone with an ether solution of hydrogen chloride and the precipitate formed was recovered by vacuum filtration. The product was crystallized from acetone-ethanol mixture to obtain 9.1 g of 2-trifluoromethyl-10-[3-(4-β-hydroxyethoxy-4-methylpiperidino)-propyl]-phenothiazine hydrochloride as white crystals melting at 218° C and soluble in ethanol, slightly soluble in acetone and insoluble in ether and water.

Provenance & Evidence