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HRID329046

反应详情

EQUATION

反应方程式

HRID 329046 的结构方程式

REACTANTS

反应物

3
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CCOCC
HCID3283

Diethyl Ether

C4H10O

结构：CC1(OCCO)CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1
HCID218108

未命名化合物

PRODUCTS

生成物

1
结构：CC1(OCCO)CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1.Cl
HCID218107

Ethanol, 2-((4-methyl-1-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-4-piperidinyl)oxy)-, monohydrochloride

C24H30ClF3N2O2S

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

The 2-trifluoromethyl-10-[3-(4-β-hydroxyethoxy-4-methyl piperidino)-propyl]-phenothiazine was reacted in acetone with an ether solution of hydrogen chloride and the precipitate formed was recovered by vacuum filtration. The product was crystallized from acetone-ethanol mixture to obtain 9.1 g of 2-trifluoromethyl-10-[3-(4-β-hydroxyethoxy-4-methylpiperidino)-propyl]-phenothiazine hydrochloride as white crystals melting at 218° C and soluble in ethanol, slightly soluble in acetone and insoluble in ether and water.

WORKUP

后处理

  1. customthe precipitate formed
  2. filtrationwas recovered by vacuum filtration
  3. customThe product was crystallized from acetone-ethanol mixture