Benzoyl isothiocyanate → N-benzoyl-N'-[3-(2-pyrazinylamino)propyl]thiourea

HRID 329090Notes

Reaction equation

[NH2:1][CH2:2][CH2:3][CH2:4][NH:5][C:6]1[CH:11]=[N:10][CH:9]=[CH:8][N:7]=1.[C:12]([N:20]=[C:21]=[S:22])(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[C:12]([NH:20][C:21]([NH:1][CH2:2][CH2:3][CH2:4][NH:5][C:6]1[CH:11]=[N:10][CH:9]=[CH:8][N:7]=1)=[S:22])(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

Reactant 2

HCID 68284Benzoyl isothiocyanate

HCID 143974072-(3-Aminopropylamino)pyrazine

Product 1

HCID 20557800N-benzoyl-N'-[3-(2-pyrazinylamino)propyl]thiourea

Procedure

Reacting 2-(3-aminopropylamino)pyrazine with benzoyl isothiocyanate by the procedure of Example 46 gives N-benzoyl-N'-[3-(2-pyrazinylamino)propyl]thiourea. Removing the benzoyl group by the procedure of Example 46 gives N-[3-(2-pyrazinylamino)propyl]thiourea.

Sources & evidence

ORD record: ord-411cf2c41ad244c5b0866461c8c05c2a
Source dataset: uspto-grants-1977_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04018931

Reaction notes

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