Sodium → 1-Oxo-2-{[(2,3,6-trimethylphenyl)methyl]sulfanyl}-1lambda~5~-pyridine

HRID 329144Notes

Reaction equation

HRID 329144 reaction equation
Br[CH2:2][C:3]1[C:4](=[C:6]([C:8](=[CH:10][CH:11]=1)[CH3:9])[CH3:7])[CH3:5].[SH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N+:14]=1[O-:19].[Na]>>[CH3:5][C:4]1[C:3]([CH3:2])=[CH:11][CH:10]=[C:8]([CH3:9])[C:6]=1[CH2:7][S:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N+:14]=1[O-:19]

Participants

4

Reactant 3

HCID 5360545SodiumHCID 9990781158549-30-5HCID 178526253HCID 178526253, compound

Product 1

HCID 540170111-Oxo-2-{[(2,3,6-trimethylphenyl)methyl]sulfanyl}-1lambda~5~-pyridineYield 50%

Procedure

The intermediate 2-(2,3,6-trimethylphenylmethylthio)pyridine N-oxide is prepared from α2 -bromoprehnitene with 2-mercaptopyridine N-oxide, sodium salt by the procedure described in Example 2. Yield 50% theory. Melting point 108° - 110° C. Structure confirmed by IR and NMR.

Sources & evidence

ORD record
ord-6367309695584f1aae9c0febc3e590ac
Source dataset
uspto-grants-1977_04
Patent number
US04019893

Reaction notes

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