反应详情

To a flask containing 46 gms. of 5-chloro-8,9-dimethoxy-1,2,4,triazolo[4,3-c]quinazoline is added 1000 ml. of a 10% KOH solution and the resulting mixture heated to reflux. A gentle reflux is maintained overnight after which time the mixture is neutralized to pH 7.0 with cooling and stirring by adding dropwise a 1:1 HCl solution and the resulting precipitate filtered off. The aqueous layer is washed 3 or 4 times with ethyl acetate, dried and evaporated in vacuo to dryness. The residue is recrystallized from ethanol to obtain 5-(2-amino-4,5-dimethoxyphenyl)-s-triazole, m.p. 205°-210° C.

1. additionTo a flask containing 46 gms
2. temperatureA gentle reflux
3. temperatureis maintained overnight after which time the mixture
4. temperaturewith cooling
5. filtrationthe resulting precipitate filtered off
6. washThe aqueous layer is washed 3 or 4 times with ethyl acetate
7. customdried
8. customevaporated in vacuo to dryness
9. customThe residue is recrystallized from ethanol