Procef → Cefprozil hydrate

HRID 32923Notes

Reaction equation

HRID 32923 reaction equation
[CH3:1]/[CH:2]=[CH:3]/[C:4]1[CH2:24][S:23][C@@H:7]2[C@H:8]([NH:11][C:12]([C@H:14]([NH2:22])[C:15]3[CH:16]=[CH:17][C:18]([OH:21])=[CH:19][CH:20]=3)=[O:13])[C:9](=[O:10])[N:6]2[C:5]=1[C:25]([OH:27])=[O:26]>CN(C=O)C>[CH3:1]/[CH:2]=[CH:3]/[C:4]1[CH2:24][S:23][C@@H:7]2[C@H:8]([NH:11][C:12]([C@H:14]([NH2:22])[C:15]3[CH:16]=[CH:17][C:18]([OH:21])=[CH:19][CH:20]=3)=[O:13])[C:9](=[O:10])[N:6]2[C:5]=1[C:25]([OH:27])=[O:26].[OH2:10]

Participants

3

Reactant 1

HCID 5281006Procef

Product 1

HCID 6436628Cefprozil hydrate

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

The aqueous solution containing Cefprozil as obtained above is converted to its DMF solvate as per the method disclosed in U.S. Pat. No. 4,694,079. The wet DMF solvate without drying is desolvated by stirring with a mixture of demineralised water (75 ml) and ethyl acetate (45 ml) for 60 minutes. The product is filtered and dried to give Cefprozil monohydrate in the form of an off white to pale yellow crystalline powder.

Workup

  1. customas obtained
  2. customwithout drying
  3. filtrationThe product is filtered
  4. customdried

Sources & evidence

ORD record
ord-152ba462b2be44bf88e9d3b07f2ceb49
Source dataset
uspto-grants-2008_09
Patent number
US07427692B2

Reaction notes

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