反应详情

Sodium hydride (0.04 mole) is added in portions with stirring to benzyl alcohol (25 ml.). To the resulting solution, ethyl 8-acetyl-12,13-epoxytridecanoate (0.02 mole) is added and the mixture allowed to stand 18 hours at 55°-60°. The reaction mixture is then cooled and treated with water. The organic layer is separated and dried over magnesium sulfate. Excess benzyl alcohol is removed by distillation in vacuo by means of the rotary evaporator at oil pump pressure. The residue consists mainly of the title compound and is used in the next step without purification.

1. temperatureThe reaction mixture is then cooled
2. customThe organic layer is separated
3. dry with materialdried over magnesium sulfate
4. customExcess benzyl alcohol is removed by distillation in vacuo by means of the rotary evaporator at oil pump pressure
5. customis used in the next step without purification