Sodium Hydroxide → 2-Ethylsulfanyl-1-(5-nitro6-trifluoromethyl-1H-indol-2-yl)-ethanol

HRID 32933Notes

Reaction equation

HRID 32933 reaction equation
[CH2:1]([S:3][CH2:4][CH:5]([C:7]1[N:8](S(C)(=O)=O)[C:9]2[C:14]([CH:15]=1)=[CH:13][C:12]([N+:16]([O-:18])=[O:17])=[C:11]([C:19]([F:22])([F:21])[F:20])[CH:10]=2)[OH:6])[CH3:2].[OH-].[Na+]>>[CH2:1]([S:3][CH2:4][CH:5]([C:7]1[NH:8][C:9]2[C:14]([CH:15]=1)=[CH:13][C:12]([N+:16]([O-:18])=[O:17])=[C:11]([C:19]([F:22])([F:20])[F:21])[CH:10]=2)[OH:6])[CH3:2]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 115024772-ethylsulfanyl-1-(1-methanesulfonyl-5-nitro-6-trifluoromethyl-1H-indol-2-yl)-ethanol

Product 1

HCID 116815332-Ethylsulfanyl-1-(5-nitro6-trifluoromethyl-1H-indol-2-yl)-ethanol

Procedure

This compound was prepared using the general de-protection procedure described in General Procedures Example B, starting from 2-ethylsulfanyl-1-(1-methanesulfonyl-5-nitro-6-trifluoromethyl-1H-indol-2-yl)-ethanol (1.52 g, 3.69 mmol) and 4M sodium hydroxide as base (1.8 mL, 7.38 mmol) to yield the title compound as a bright yellow solid.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-38b43f83509a41fe8be53869d03cf5d2
Source dataset
uspto-grants-2008_09
Patent number
US07427682B2

Reaction notes

Loading…