Hydrochloric Acid → beta-N,N-dimethylaminoethyl 2-(5-oxo-5H-dibenzo[a,d]cyclohepten-2-yl)propionate hydrochloride

HRID 329335Notes

Reaction equation

HRID 329335 reaction equation
[O:1]=[C:2]1[C:8]2[CH:9]=[CH:10][C:11]([CH:13]([CH3:22])[C:14]([O:16][CH2:17][CH2:18][N:19]([CH3:21])[CH3:20])=[O:15])=[CH:12][C:7]=2[CH:6]=[CH:5][C:4]2[CH:23]=[CH:24][CH:25]=[CH:26][C:3]1=2.[ClH:27]>C(OCC)C>[ClH:27].[O:1]=[C:2]1[C:8]2[CH:9]=[CH:10][C:11]([CH:13]([CH3:22])[C:14]([O:16][CH2:17][CH2:18][N:19]([CH3:21])[CH3:20])=[O:15])=[CH:12][C:7]=2[CH:6]=[CH:5][C:4]2[CH:23]=[CH:24][CH:25]=[CH:26][C:3]1=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 12398827HCID 12398827, compound

Product 1

HCID 12398828beta-N,N-dimethylaminoethyl 2-(5-oxo-5H-dibenzo[a,d]cyclohepten-2-yl)propionate hydrochloride

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

0.51 G. of β-N,N-dimethylaminoethyl 2-(5-oxo-5H-dibenzo[a,d]cyclohepten-2-yl)propionate is dissolved in about 25 ml. of diethyl ether and hydrochloric acid gas is passed therethrough to give a precipitate. The ether is decanted, and the precipitate washed with ether, dried under vacuum, and then recrystallized from isopropanol/ether to give β-N,N-dimethylaminoethyl 2-(5-oxo-5H-dibenzo[a,d]cyclohepten-2-yl)propionate hydrochloride (m.p. 136°-137° C).

Workup

  1. customto give a precipitate
  2. customThe ether is decanted
  3. washthe precipitate washed with ether
  4. customdried under vacuum
  5. customrecrystallized from isopropanol/ether

Sources & evidence

ORD record
ord-9cf7f9249e2a4ef399da944e5a2efb89
Source dataset
uspto-grants-1977_04
Patent number
US04020094

Reaction notes

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