反应详情

温度

100 °C

Aniline (0.93 g), 1-iodohexadecane (10.56 g) and diisopropylethylamine (2.58 g) were combined in 10 ml of toluene. The mixture was heated at about 100° C. for a period of three days. The mixture was chromatographed on a silica gel column using 1% ethyl acetate in hexane. The heavy crystalline mass that precipitated from solution was cooled, diluted with ether and filtered. The filtrate was concentrated to an oil and applied to a silica gel column. The oil was washed with 500 ml of hexane followed by 1% ethyl acetate in hexane. The dialkylated fractions were combined and evaporated to give 2.6 grams of product.

1. customThe mixture was chromatographed on a silica gel column
2. customThe heavy crystalline mass that precipitated from solution
3. temperaturewas cooled
4. additiondiluted with ether
5. filtrationfiltered
6. concentrationThe filtrate was concentrated to an oil
7. washThe oil was washed with 500 ml of hexane
8. customevaporated