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HRID329355

反应详情

EQUATION

反应方程式

HRID 329355 的结构方程式

REACTANTS

反应物

3
结构：Cc1ccc(S(=O)(=O)O)cc1
HCID6101

4-Methylbenzenesulfonic acid

C7H8O3S

结构：Cc1ccc(S(=O)(=O)NN)cc1
HCID15303

Toluene-4-sulphonohydrazide

C7H10N2O2S

结构：C[C@]12CC=CC[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12
HCID101928

5alpha-Androst-2-en-17-one

C19H28O

PRODUCTS

生成物

1
结构：Cc1ccc(S(=O)(=O)NN=C2CC[C@H]3[C@@H]4CC[C@H]5CC=CC[C@]5(C)[C@H]4CC[C@]23C)cc1
HCID86743630

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

2 次

PROCEDURE

实验过程

4-Methylbenzenesulphonic acid hydrazide (525 g) and 4-methylbenzenesulphonic acid (5.25 g) were added to a hot, stirred solution of (5α)-androst-2-en-17-one (700 g) in ethanol (5.6 l) and the solution was heated under reflux for 8 h. The stirred mixture was cooled and further ethanol (1 l) was added to give 4-methylbenzenesulphonic acid [(5α)-androst-2-en-17-ylidene]hydrazide as a crystalline solid.

WORKUP

后处理

  1. temperaturethe solution was heated
  2. temperatureunder reflux for 8 h
  3. temperatureThe stirred mixture was cooled