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HRID329356

反应详情

EQUATION

反应方程式

HRID 329356 的结构方程式

REACTANTS

反应物

4
结构：O
HCID962

Water

H2O

结构：Cc1ccc(S(=O)(=O)Cl)cc1
HCID7397

p-Toluenesulfonyl chloride

C7H7ClO2S

结构：C[C@]12CC[C@H](O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)C=CC[C@@H]12
HCID151449

3beta-Androstenol

C19H30O

结构：C[C@]12CC[C@H](O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12
HCID441302

Epiandrosterone

C19H30O2

PRODUCTS

生成物

1
结构：C[C@]12CC[C@H](O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)C=CC[C@@H]12.Cc1ccc(S(=O)(=O)[O-])cc1
HCID86743631

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：c1ccncc1
溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

4-Methylbenzenesulphonyl chloride (20 g) was added to a stirred solution of (3β, 5α)-androst-16-en-3-ol (20 g), which was prepared from (3β, 5α)-androstan-3-ol- 17-one in a similar way as described in Examples 1 and 2, in pyridine (100 ml) at °C. The mixture was stirred at 0°-5° C. for 1 h., then set aside in a refrigerator for 3 d. Water was added to precipitate the product as off-white prisms. Recrystallisation from diethyl ether-methanol gave colourless prisms of (3β, 5α)-androst-16-en-3-ol 4-methylbenzenesulphonate, Which Was treated as described in Example 3.

WORKUP

后处理

  1. waitset aside in a refrigerator for 3 d
  2. customto precipitate the product as off-white prisms
  3. customRecrystallisation from diethyl ether-methanol