HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 3beta-(Cyclopentanepropionyloxy)-17beta-(cyclopropyloxy)androst-5-ene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 17beta-(Cyclopropyloxy)androst-5-en-3beta-ol | HCID 14882764 | — |
| Reactant | 3beta-Acetyloxy-17beta-(cyclopropyloxy)androst-5-ene | HCID 67896754 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3beta-(Cyclopentanepropionyloxy)-17beta-(cyclopropyloxy)androst-5-ene | HCID 67896728 | — |
| Product | 3beta-(Benzenepropionyloxy)-17beta-(cyclopropyloxy)androst-5-ene | HCID 67896733 | — |
Reaction Steps
17β-(Cyclopropyloxy)androst-5-en-3β-ol is treated with acetic anhydride and pyridine. The mixture is poured into water and extracted with ethyl acetate. The ethyl acetate layer is separated and dried and the solvent is evaporated to leave as a residue, 3β-acetyloxy-17β-(cyclopropyloxy)androst-5-ene. 3β-(Cyclopentanepropionyloxy)-17β-(cyclopropyloxy)androst-5-ene and 3β-(benzenepropionyloxy)-17β-(cyclopropyloxy)androst-5-ene are obtained in a similar way using the appropriate acid chlorides.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04891367 |
| Source dataset | uspto-grants-1990_01 |
| ORD ID | ord-bdfbd80731cb4520bdc5223c24f1037a |
| Source note | uspto-grants-1990_01 |