反应详情

A mixture of 4-nitrophenol (139 g, 1 mole), 2-(benzenesulphonyloxy)ethyl chloride (220.5 g, 1 mole--see Ber. (1920), 53, 1836) and anhydrous potassium carbonate (138 g, 1 mole) in methyl ethyl ketone ("MEK"--1000 ml) was stirred at reflux for 16 hours. After cooling, the mixture was poured onto water and the organic layer was separated. Following two further extractions with methyl ethyl ketone, the combined organic fractions were dried (MgSO4), filtered and evaporated. The resultant solid was crystallised from ethanol to give the title compound, (165.8 g), m.p. 60°.

1. temperatureat reflux for 16 hours
2. temperatureAfter cooling
3. additionthe mixture was poured onto water
4. customthe organic layer was separated
5. extractiontwo further extractions with methyl ethyl ketone
6. dry with materialthe combined organic fractions were dried (MgSO4)
7. filtrationfiltered
8. customevaporated
9. customThe resultant solid was crystallised from ethanol