Ethyl Acetate → HCID 19872052, compound

HRID 329378Notes

Reaction equation

HRID 329378 reaction equation
[NH2:1][C:2]1[CH:24]=[CH:23][C:5]([O:6][CH2:7][CH2:8][N:9]2[CH2:15][CH2:14][C:13]3[CH:16]=[CH:17][C:18]([N+:20]([O-])=O)=[CH:19][C:12]=3[CH2:11][CH2:10]2)=[CH:4][C:3]=1[CH3:25].C(OCC)(=O)C>[Pd].CO>[NH2:20][C:18]1[CH:17]=[CH:16][C:13]2[CH2:14][CH2:15][N:9]([CH2:8][CH2:7][O:6][C:5]3[CH:23]=[CH:24][C:2]([NH2:1])=[C:3]([CH3:25])[CH:4]=3)[CH2:10][CH2:11][C:12]=2[CH:19]=1

Participants

5

Reactant 2

HCID 8857Ethyl AcetateHCID 19872054HCID 19872054, compound

Product 1

HCID 19872052HCID 19872052, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

3-[2-(4-Amino-3-methylphenoxy)ethyl]-7-nitro-1,2,4,5-tetrahydro-3H-3-benzazepine (0.5 g) was stirred at room temperature under a hydrogen atmosphere [344.7 kPa (50 p.s.i.)]in ethyl acetate (20 ml) and methanol (20 ml) containing 5% Pd/C (0.075 g) for 3 hours. The catalyst was then removed by filtration and the filtrate was evaporated in vacuo to give the title compound as an oil, yield 0.385 g, which was used directly without further purification.

Workup

  1. customThe catalyst was then removed by filtration
  2. customthe filtrate was evaporated in vacuo

Sources & evidence

ORD record
ord-edd6f35068fd48c28591276bef998b3f
Source dataset
uspto-grants-1990_01
Patent number
US04891372

Reaction notes

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