反应详情

To a 35 ml round-bottomed flask equipped with condenser and N2 inlet were added 0.75 g (2.59 mmol) of 4-(4-(2-chloroethyl)phenyl)-2-aminothiazole hydrobromide, 0.69 g (2.59 mmol) of N-(3-trifluoromethylphenyl)piperazine hydrochloride, 1.08 ml (7.78 mmol) of triethylamine, 0.27 g (2.59 mmol) of sodium carbonate, 5 mg of sodium iodide, and 9.5 ml of ethanol. The reaction was heated at reflux, cooled, and taken up in ethyl acetate/water. The layers were separated, the ethyl acetate washed with brine, dried, and evaporated to give an oil. The oil was chromatographed on silica gel using ethyl acetate as eluent to give an oil. The oil was taken up in ethyl acetate/methanol, ether saturated with HCl was added, the precipitate filtered, washed with ether, and dried to give a white solid, 0.72 g (50%), m.p. 110°-115° C.

1. customTo a 35 ml round-bottomed flask equipped with condenser and N2 inlet
2. temperatureThe reaction was heated
3. temperatureat reflux
4. temperaturecooled
5. customThe layers were separated
6. washthe ethyl acetate washed with brine
7. customdried
8. customevaporated
9. customto give an oil
10. customThe oil was chromatographed on silica gel
11. customto give an oil
12. filtrationthe precipitate filtered
13. washwashed with ether
14. customdried
15. customto give a white solid, 0.72 g (50%), m.p. 110°-115° C.