2-Methylimidazole → HCID 13986706, compound

HRID 329443Notes

Reaction equation

HRID 329443 reaction equation
Cl[CH2:2][C:3]([N:5]([C:15]1[C:20]([CH3:21])=[CH:19][CH:18]=[CH:17][C:16]=1[CH3:22])[CH2:6][CH2:7][CH2:8][C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)=[O:4].[Na].[CH3:24][C:25]1[NH:26][CH:27]=[CH:28][N:29]=1>>[CH3:22][C:16]1[CH:17]=[CH:18][CH:19]=[C:20]([CH3:21])[C:15]=1[N:5]([CH2:6][CH2:7][CH2:8][C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)[C:3](=[O:4])[CH2:2][N:26]1[CH:27]=[CH:28][N:29]=[C:25]1[CH3:24]

Participants

4

Reactant 3

HCID 127492-MethylimidazoleHCID 5360545SodiumHCID 14851587HCID 14851587, compound

Product 1

HCID 13986706HCID 13986706, compound

Procedure

This material was prepared in an analogous manner as the previous example from 2.9 g of 2-chloro-N-(2,6-dimethylphenyl)-N-[3-(3-pyridinyl)propyl]acetamide and the sodium salt of 2-methyl imidazole. After filtration through silica gel, the residue (3 g) was crystallized from ethyl acetate-hexane to give 2.1 g of analytically pure free base, mp 89°-90° C.

Workup

  1. filtrationAfter filtration through silica gel
  2. customthe residue (3 g) was crystallized from ethyl acetate-hexane
  3. customto give 2.1 g of analytically pure free base, mp 89°-90° C.

Sources & evidence

ORD record
ord-a6bdcb161cf048798cd847b14d7753ab
Source dataset
uspto-grants-1990_01
Patent number
US04891429

Reaction notes

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